Click Here to Subscribe:
Website:
Get the Apparel I Wear at www.
Do Vitamins Break a Fast? Supplements and Intermittent Fasting
Study – Rejuvenation Research
To understand how fasting might make cells stronger, researchers recruited 24 people and asked them to practice an intermittent fasting diet for two three-week periods
The study was designed as a 10-week double-crossover trial, consisting of two 3-week treatment periods – IF and IF with antioxidant supplementation
Each 3-week treatment period was preceded by a 1-week pre-conditioning period used to establish baseline caloric intake and to acclimate the participants to study-provided food.
During the first fasting period, participants ate a specially calibrated diet and during the second three week period, they ate that diet and took oral supplements of Vitamin C and Vitamin E
Because researchers just wanted to focus on how intermittent fasting affected cells, and not weight loss, participants ate 175% of their normal daily calorie intake on feasting days, and 25% of their normal daily intake on fasting days to prevent weight loss
They ate typical American food – things like pasta, chicken, sandwiches and desserts like ice cream, and took samples of blood before they started and just after they ended the diet so they could compare levels of byproducts of oxidative stress and markers of strong cell functioning
During the first three week period researchers attempted to see if fasting would increase oxidative stress (free radicals) in each person’s cells and to see if this stress actually led to stronger, more resilient cells
Looked to see if taking antioxidants in the second fasting period would block the free radicals caused by the fasting, preventing the cells from becoming more resilient
In other words, they wanted to know if Vitamin C and E would shelter the cells to the point that they wouldn’t be ready to stand up for themselves later on
Results
Found that in response to fasting every other day, the cells made more copies of a gene called SIRT3, which is part of a pathway that works to prevent free radical production and improve cellular repair processes
Specifically, there was a 2.7% increase in SIRT3 expression due to the IF diet, but no change in expression of other genes or oxidative stress markers analyzed
Also found a significant decrease in levels of circulating insulin, a sign that the participants bodies were more responsive to this hormone
One surprising finding is that when participants took daily oral supplements of Vitamin C and E, the benefits from fasting disappeared
It seems that because the cells were relatively sheltered from experiencing any oxidative stress that may have been caused by fasting every other day, they didn’t respond by increasing their natural defenses and improving their sensitivity to insulin and other stress signals
This suggests that low levels of environmental stress from things like fasting are actually good for our bodies, and that antioxidant supplements, while potentially good at certain times, might actually prevent our normal healthy cellular responses in other situations
Antioxidants & Autophagy
In turns out that some level of ROS production is required for the normal regulation of autophagy as well
A team of researchers at the University of Cambridge explored the relationship between autophagy and the production or reactive oxidative species
They found that it is possible to induce autophagy without increasing toxic ROS and that some antioxidants reduce autophagy
They looked at two types of non-HD cells (HeLa and COS-7 renal cells), adding rapamycin, an antibiotic, and trehalose, a sugar, both of which have been shown to induce autophagy
Each increased autophagy but neither increased ROS.
Next they looked at the effect of various antioxidants on autophagy in the COS-7 renal cells.
Autophagy was measured by levels of LC3-II, a marker for autophagosome formation and autophagosome-lysosome fusion
They looked at N-acetyl-cysteine (NAC), cystamine (in the pipeline as a potential HD treatment), and glutathione
All three impaired the induction of autophagy by trehalose in a dose dependent manner – they also looked at the effect of NAC and cystamine on rapamycin induced autophagy and on basal (normal, not induced levels of) autophagy and got similar results.
Also found that vitamin E impaired autophagy as well
Resources
1)
2)
3)
source: https://sebastienizambard.net/
Xem thêm các bài viết về Sức Khỏe: https://sebastienizambard.net/category/suc-khoe/
MrDae006 says:
How about medications (Statins and Lisinopril). I Fast 20 hours every other day. I'm 52 and starting at this rate for right now. Should I only take these meds during my eating stage or can I take them while fasting? Thanks
Horseteeth Gaming says:
I just realized that my magnesium that I take has rice bran extract in the "other ingredients." Is this okay? Is it such a small amount that it wont matter or will that screw me up on keto? I also got a potassium supplement and some bone broth travel sticks at costco. I really don't want to get weak this time doing keto and feel like i'm going to faint.
Tahera Cosic says:
Does anti depressant medication taken during my fast break my fast? I cant seem to get an answer anywhere.
Mika says:
Does ACV break a fast?
Jessica Vandyke says:
Does glucomannan powder break a fast?
thesoundpurist says:
your stuff is freaking informative and I'm confident you gonna improve volume quality on the videos.
Rossco298 says:
latest performence apparel
you make me want to empty my wallet lol
Eugene Rojas says:
Hey Thomas, I have a question, I started to use Ritalin, taking methylphenidate alters cortisol? And take it break fast or alters autophagy?
Jason Ash says:
Hi Thomas, may I ask, what about C4, the pre workout supplement? Every ingredient it has are fine to take when fasting but I'm not sure about the Vitamin B inside. Is C4 be a pre workout supplement that we can take without breaking a fast? Many thanks!
RANDBO says:
@Thomas Delauer Do Hot Herbal/Medicinal Teas Break The Benefits of A Fast? Intermittent or Extended? Im about 40hrs in. Thx
Natis Bado says:
Do steroids break Thomas' fast ?? 😀
Dante says:
My reaction to like most of Thomas Delauer's video's 5:17
Sid Sid says:
Hi Thomas, so you mean we shouldnt take glutathione supplements on a extended fast and IF. So do antioxidants block autophagy ?Is this correct ?
Julie Russell says:
Hi Thomas! I know this is about vit supplements, but what can I do if I am on a daily thyroid pill first thing in am then eat 30 min later; and I also take Metformin twice a day recommended with food? I am already on Keto and in Ketosis but want to fix my metobolic syndrome. Thanks so much love your channel. You have a gift!
samuel sam says:
Question plz moringa and spirulina ok to take while fasting or no tx
RaRa Da Ram says:
Does creatine break a fast?
Daniel Docherty says:
Will my acv, cream of tartar and sodium drink in the morning before work break my fast? I'm only asking as do far it helps massively. Thanks in advance.
MIXED TEA says:
What about adding fish oil & magnesium?
I was going to add magnesium, fish oil & Himalayan salt to my water during a 5-7 day fast.
thewikwakdj says:
What about medication. Does that break a fast? Such as blood pressure meds?
Nato Sincere says:
If I work out while in my fasting window. Do I stop taking pre workout supplements? I usually finish my workout and then start my eating window. Do I just stick to post work out?
Justin Bayless says:
What would you recommend to someone eating one meal a day in the evenings? I have a multivitamin in addition to a zero calorie greens supplement that I typically would have taken in the mornings or lunch whenever my first meal was. Do I take them fasted or wait until my mealtime in the evening
MasonDubbs says:
Do thermogenics break a fast?
Wayne Hughes says:
The idea is to force your body to survive/balance by itself during that window, so green tea, coffee, vitamins/mineral, etc. This micronutrients are perceived as help, not as big as macronutrients but still a small help.
Pauline Ayaay says:
Hi Thomas can I still drink my collagen tablets and hormones during my water fasting tnx
DiRRTYSiX BJR says:
What about on a long term water fast say about 2 weeks……would it be beneficial then to take a multivitamin pack
Mariah Alterio says:
What about taking calcium and magnesium while doing a 14 day water fast
Ryan Buss says:
Will salt lower your autophagy while fasting?
hannahmitchell87 says:
Can anyone tell me whether pain medication breaks/negatively affects a fast please? Sorry if I've missed the info! Thanks in advance! Xxx
Eric Meador says:
What about appetite suppressors like hydroxycut?
Nikos Kokon says:
Does anavar (oxandrolone) break your fast? It has vitamin b1 , 6 & 12 inside too
Veronica Rodriguez says:
I'm wondering if probiotics have the same effect since they aren't vitamins or minerals but good bacteria for your gut. Will that effect a fast?
Greg James says:
Does Acetyl L-Carnatine break the fast?
Mi Yuki says:
Im doing a water fast for a week, do diet pills break the fast?
石頭廖 says:
Does carnitine affect 20-4 fasting benefits ? Thanks your reply
Apex Predator says:
So drink green tea or not on a fast? What about w/ coffee cacao, cinnamon, reishi, cordyceps, lions mane? Do all antioxidants inhibit autophagy or only particular ones?
Patrick Vollen says:
Thomas, do you think is it wise to take vitamin d during a fast?
M. Malika says:
Make short videos like dr berg. This is boring to much talk